Active substance: mercaptopurine (mercaptopurine). Pharmachologic effect: Purinethol has antitumor and immunosuppressive effects. It is a competitive antagonist of purine bases. Indications for use: acute lymphoblastic leukemia; acute myeloid leukemia; chronic myeloid leukemia (induction of remission and maintenance therapy). Purinethol can be used both as monotherapy and in conjunction with other cytostatic in various doses, based on the therapy strategy. Normally for adults and children, the dose is 50-75 mg / m2 or 2.5 mg / kg / day; Later, everyday Purinethol dose is altered dependant upon the effect. At first symptoms of severe leukopenia, it is recommended to interrupt the ingestion for 2-3 days. If leukopenia does not intensify during this time of time, the therapy is started again. In seniors sufferers, it is advised to watch hardworking liver and kidney function. If warning signs of kidney or hepatic failing are detected, the dosage needs to be lowered. The the dose also need to be decreased for individuals with hepatic and / or renal deficiency.When coupled with allopurinol, the dose of Mercaptopurine is decreased to 25% of the normal dosage, since allopurinol reduces the metabolic rate of Mercaptopurine. Buy acheter Mercaptopurine pas cher without prescription on the net at the finest selling price.
Negative effects. From the side of hematopoiesis: often - leukopenia, thrombocytopenia, anemia. Reactions from the body's defense mechanisms: sensitivity reactions: rarely - arthralgia, skin allergy, drug fever; seldom - inflammation. On the gastrointestinal system part: often - nausea, vomiting, anorexia, intrahepatic cholestasis, hepatotoxicity (hepatotoxicity has a toxic-allergic genesis and takes place when the encouraged medication dosage of 2.5 mg / kg / day or 75 mg / m2 / day is surpassed; almost never - ulceration of the oral mucosa, diarrhea, pancreatitis, hepatonecrosis; rarely - ulceration of the intestinal tract mucosa. Other: decreased immunity, accession of secondary infections, skin hyperpigmentation; hyperuricemia and nephropathy due to tumor lysis; very rarely - the development of secondary leukemia, myelodysplasia and hepatolienal T-cell lymphoma. Click the hyperlink for Additional information on Purinethol France and finest destination to get Purinethol for reasonable.
Advisable limitations for use are the following: carrying a child; lactation period, allergic reaction to Mercaptopurine or other parts of the drug.
Over dose signs: immediate - queasiness, vomiting, anorexia, diarrhea; postponed - myelosuppression, hardworking liver dysfunction, gastroenteritis. Special directions! Purinethol should be used only under doctor’s supervision and the medical professional must have experience in the use of cytostatics. Therapy should be completed under health-related supervision. Do not hesitate to follow the hyperlink for more info about Mercaptopurine France and finest website to buy Acheter Purinethol sans ordonnance Without Medical prescription for affordable.